Pyroptosis in inflammation-related respiratory disease

Y Feng, M Li, X Yangzhong, X Zhang, A Zu… - Journal of physiology …, 2022 - Springer
Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by
the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing …

Recent advances in toxicological research and potential health impact of microplastics and nanoplastics in vivo

Q Zhang, Y He, R Cheng, Q Li, Z Qian, X Lin - Environmental Science and …, 2022 - Springer
As emerging pollutants, direct and indirect adverse impacts of micro (nano) plastics
(MPs/NPs) are raising an increasing environmental concern in recent years due to their poor …

Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis

F Han, S Li, Y Yang, Z Bai - Bioengineered, 2021 - Taylor & Francis
Asthma occurs accompanied by the ferroptosis in bronchial epithelial cells, during which
Interleukin-6 (IL-6) plays a key role. However, the associations between IL-6, ferroptosis and …

Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis

H Zhou, W Zhang, D Qin, P Liu, W Fan, H Lv… - International …, 2022 - Elsevier
Objective Allergic rhinitis (AR) is a heterogeneous disease and its pathogenesis is still
unclear. Growing clinical evidence has thrown light on the key role of NOD-like Receptor …

Schisandrin B attenuates airway inflammation and airway remodeling in asthma by inhibiting NLRP3 inflammasome activation and reducing pyroptosis

X Chen, Z Xiao, Z Jiang, Y Jiang, W Li, M Wang - Inflammation, 2021 - Springer
Asthma is a chronic inflammatory disorder of the airways. Schisandrin B (SB) is the main
effective component. This study investigated the effects of SB on airway inflammation and …

Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production

N Song, X Li, Y Cui, T Zhang, S Xu, S Li - Journal of hazardous materials, 2021 - Elsevier
Hydrogen sulfide (H 2 S) is an air pollutant to cause tracheal injury. Pyroptosis is
responsible for tissue injury through reactive oxygen species (ROS) production. Competitive …

Pyroptosis: a promising therapeutic target for noninfectious diseases

T Li, G Zheng, B Li, L Tang - Cell proliferation, 2021 - Wiley Online Library
Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation,
cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell …

HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma

Z Zeng, H Huang, J Zhang, Y Liu, W Zhong… - The FASEB …, 2022 - Wiley Online Library
Asthma is a disease characterized by airway epithelial barrier destruction, chronic airway
inflammation, and airway remodeling. Repeated damage to airway epithelial cells by …

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

YS Fu, N Kang, Y Yu, Y Mi, J Guo, J Wu… - European Respiratory …, 2022 - Eur Respiratory Soc
COPD is predicted to become the third leading cause of morbidity and mortality worldwide
by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of …

ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress/pyroptosis axis

QL Wang, W Xing, C Yu, M Gao, LT Deng - Molecular Immunology, 2021 - Elsevier
Background It has been reported that ROCK1 participates in the progression of multiple
diseases, including septic intestinal barrier, cardiac dysfunction and acute lung injury …