A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac anomaly, in which the
valve has only two leaflets, instead of the normal three. Patients with a BAV have an …

Development of the heart is a very intricate and multiplex process as it involves not only the
three spatial dimensions but also the fourth or time dimension. Over time, the heart of an …

Background Thoracic aortopathy is a serious complication which is more often seen in
patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) than in …

The transforming growth factor beta (TGFβ) and Hippo signaling pathways are evolutionarily
conserved pathways that play a critical role in cardiac fibroblasts during embryonic …

Cardiogenesis is similar in all vertebrates, but differences in the valvuloseptal
morphogenesis among non‐crocodilian reptiles, birds, and mammals are noted. The origin …

Background Recent reports confirmed the notion that there exists a rudimentary cardiac
conduction system (CCS) in the crocodylian heart, and development of its ventricular part is …

A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is
associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic …

This Introduction provides both a short reflection on the scientific career of Adriana
Gittenberger-de Groot and an overview of the papers that form the basis of this Special Issue …

Physical exercise is the greatest stress on the cardiovascular system, not only in humans but
also in all vertebrates. Consequently, the cardiovascular response cannot be thought of as …

A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is
associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic …