Coronary blood flow in heart failure: cause, consequence and bystander
G Heusch - Basic research in cardiology, 2022 - Springer
Heart failure is a clinical syndrome where cardiac output is not sufficient to sustain adequate
perfusion and normal bodily functions, initially during exercise and in more severe forms …
perfusion and normal bodily functions, initially during exercise and in more severe forms …
[HTML][HTML] Gene therapy in cardiology: is a cure for hypertrophic cardiomyopathy on the horizon?
ED Paratz, J Mundisugih, SJ Rowe, E Kizana… - Canadian Journal of …, 2023 - Elsevier
Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy world-wide,
affecting approximately 1 in 500 individuals. Current therapeutic interventions comprise …
affecting approximately 1 in 500 individuals. Current therapeutic interventions comprise …
Effects of metoprolol on exercise hemodynamics in patients with obstructive hypertrophic cardiomyopathy
AM Dybro, TB Rasmussen, RR Nielsen… - Journal of the American …, 2022 - jacc.org
Background The relationship between exercise hemodynamics, loading conditions, and
medical treatment in patients with obstructive hypertrophic cardiomyopathy (HCM) is …
medical treatment in patients with obstructive hypertrophic cardiomyopathy (HCM) is …
The interventricular septum: structure, function, dysfunction, and diseases
F Triposkiadis, A Xanthopoulos, KD Boudoulas… - Journal of clinical …, 2022 - mdpi.com
Vertebrates developed pulmonary circulation and septated the heart into venous and arterial
compartments, as the adaptation from aquatic to terrestrial life requires more oxygen and …
compartments, as the adaptation from aquatic to terrestrial life requires more oxygen and …
CRISPR/CAS9: a promising approach for the research and treatment of cardiovascular diseases
M Dong, J Liu, C Liu, H Wang, W Sun, B Liu - Pharmacological Research, 2022 - Elsevier
The development of gene-editing technology has been one of the biggest advances in
biomedicine over the past two decades. Not only can it be used as a research tool to build a …
biomedicine over the past two decades. Not only can it be used as a research tool to build a …
Evolution of genetic testing and gene therapy in hypertrophic cardiomyopathy
K Chiswell, L Zaininger, C Semsarian - Progress in Cardiovascular …, 2023 - Elsevier
Studies over the last 30 years have identified hypertrophic cardiomyopathy (HCM) as
predominantly an autosomal dominant disorder caused by disease-causing variants in …
predominantly an autosomal dominant disorder caused by disease-causing variants in …
[HTML][HTML] Treatment strategies for hypertrophic cardiomyopathy: Alcohol septal ablation and procedural step-by-step technique
Alcohol septal ablation (ASA) is a well-established procedure for septal reduction therapy in
patients with obstructive hypertrophic cardiomyopathy, significant at rest or provocable …
patients with obstructive hypertrophic cardiomyopathy, significant at rest or provocable …
FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System
B Li, F Liu, X Chen, T Chen, J Zhang, Y Liu, Y Yao… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common heritable heart disease.
Although HCM has been reported to be associated with many variants of genes involved in …
Although HCM has been reported to be associated with many variants of genes involved in …
Low T3 syndrome predicts more adverse events in patients with hypertrophic cardiomyopathy
CJ He, CY Zhu, HY Fan, YZ Qian, CL Zhai… - Clinical …, 2023 - Wiley Online Library
Background Hypertrophic cardiomyopathy (HCM) is a common cardiac genetic disorder that
clinically manifests with sudden death and progressive heart failure. Moreover, thyroid …
clinically manifests with sudden death and progressive heart failure. Moreover, thyroid …
[HTML][HTML] Remodelling of potassium currents underlies arrhythmic action potential prolongation under beta-adrenergic stimulation in hypertrophic cardiomyopathy
R Doste, R Coppini, A Bueno-Orovio - Journal of Molecular and Cellular …, 2022 - Elsevier
Hypertrophic cardiomyopathy (HCM) patients often present an enhanced arrhythmogenicity
that can lead to lethal arrhythmias, especially during exercise. Recent studies have …
that can lead to lethal arrhythmias, especially during exercise. Recent studies have …