Homologous recombination (HR) repair deficiency impairs the proper maintenance of
genomic stability, thus rendering cancer cells vulnerable to loss or inhibition of DNA repair …

PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …

Abstract The Ensembl Variant Effect Predictor is a powerful toolset for the analysis,
annotation, and prioritization of genomic variants in coding and non-coding regions. It …

PARP inhibitors (PARPi) prevent cancer cell growth by inducing synthetic lethality with DNA
repair defects (eg, in BRCA1/2 mutant cells). We have identified an alternative pathway for …

The roles of R-loops and RNA modifications in homologous recombination (HR) and other
DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

In this review, we outline recent advancements in small molecule drug design from a
structural perspective. We compare protein structure prediction methods and explore the …

Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …

Recently, molecular hybridization paradigm became an interesting and smart way to defeat
the multifaceted cancer disease by a single molecular entity that acts via several …

Next-generation sequencing technology has enabled the comprehensive detection of
genomic alterations in human somatic cells, including point mutations, chromosomal …