Agricultural and household applications of pyrethroid insecticides have significantly
increased residual concentrations in living cells and environments. The enhanced …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

Data-independent acquisition (DIA) proteomics is a recently-developed global mass
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …

UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …

In this study, a two-photon ratiometric fluorescent probe NCEN has been designed and
developed for highly selective and sensitive sensing of human carboxylesterase 2 (hCE2) …

Carboxylesterases (CEs) are widely distributed in the body and catalyze the hydrolysis of
endogenous and exogenous substrates. They play important roles in drug metabolism, and …

Despite data-independent acquisition (DIA) has been increasingly used for relative protein
quantification, DIA-based label-free absolute quantification method has not been fully …

Targeted quantitative proteomics using heavy isotope dilution techniques is increasingly
being utilized to quantify proteins, including UGT enzymes, in biological matrices. Here we …

The aim of this study was to optimize methods for quantifying 13 uridine 5′-diphosphate-
glucuronosyltransferase (UGT) isoforms (UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10 …