Life at the crossroads: the nuclear LINC complex and vascular mechanotransduction

P Bougaran, VL Bautch - Frontiers in Physiology, 2024 - frontiersin.org
Vascular endothelial cells line the inner surface of all blood vessels, where they are
exposed to polarized mechanical forces throughout their lifespan. Both basal substrate …

Bone morphogenetic protein signalling in pulmonary arterial hypertension: revisiting the BMPRII connection

W Li, K Quigley - Biochemical Society Transactions, 2024 - portlandpress.com
Pulmonary arterial hypertension (PAH) is a rare and life-threatening vascular disorder,
characterised by abnormal remodelling of the pulmonary vessels and elevated pulmonary …

KRIT1 in vascular biology and beyond

AJ Glading - Bioscience Reports, 2024 - portlandpress.com
KRIT1 is a 75 kDa scaffolding protein which regulates endothelial cell phenotype by limiting
the response to inflammatory stimuli and maintaining a quiescent and stable endothelial …

Pioneering the future: CRISPR-Cas9 gene therapy for hereditary hemorrhagic telangiectasia. Author's reply

P Cerdà, C Aguilera, A Riera-Mestre - European Journal of Internal …, 2024 - ejinme.com
We read the recent innovative Letter by James and Sehgal, commenting on our article
published in the European Journal of Internal Medicine and advocating for the development …

Recent Advances in Hereditary Hemorrhagic Telangiectasia Pathogenesis and Therapies

Y Alka, Z Shabani, JK Dhaliwal, A Schmidt, H Su - 2024 - preprints.org
Abstract Hereditary Hemorrhagic Telangiectasia (HHT), also known as Osler-Weber-Rendu
syndrome, is a rare and inherited vascular disorder, characterized by the development of …

[PDF][PDF] Integration of genotypic data into clinical trial design and reporting in hereditary hemorrhagic telangiectasia could help personalize treatment

A Modarresi, CL Shovlin - Haematologica, 2020 - haematologica.org
Integration of genotypic data into clinical trial design and reporting in hereditary
hemorrhagic telangiectasia could help perso Page 1 Integration of genotypic data into …