The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

The social salience hypothesis of oxytocin

SG Shamay-Tsoory, A Abu-Akel - Biological psychiatry, 2016 - Elsevier
Oxytocin is a nonapeptide that also serves as a neuromodulator in the human central
nervous system. Over the last decade, a sizeable body of literature has examined its effects …

[HTML][HTML] Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats

VEM Oliveira, M Lukas, HN Wolf, E Durante… - Nature …, 2021 - nature.com
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we
established a rat model of enhanced aggression in females using a combination of social …

Detection, processing and reinforcement of social cues: regulation by the oxytocin system

R Menon, ID Neumann - Nature Reviews Neuroscience, 2023 - nature.com
Many social behaviours are evolutionarily conserved and are essential for the healthy
development of an individual. The neuropeptide oxytocin (OXT) is crucial for the fine-tuned …

Fighting females: neural and behavioral consequences of social defeat stress in female mice

EL Newman, HE Covington III, J Suh, MB Bicakci… - Biological …, 2019 - Elsevier
Background Despite the twofold higher prevalence of major depressive and posttraumatic
stress disorders in women compared with men, most clinical and preclinical studies have …

[HTML][HTML] Wireless optogenetic stimulation of oxytocin neurons in a semi-natural setup dynamically elevates both pro-social and agonistic behaviors

S Anpilov, Y Shemesh, N Eren, H Harony-Nicolas… - Neuron, 2020 - cell.com
Complex behavioral phenotyping techniques are becoming more prevalent in the field of
behavioral neuroscience, and thus methods for manipulating neuronal activity must be …

[HTML][HTML] Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens

AV Williams, N Duque-Wilckens… - …, 2020 - nature.com
Oxytocin is currently being considered as a novel therapeutic for anxiety disorders due to its
ability to promote affiliative behaviors. In the nucleus accumbens (NAc) activation of oxytocin …

Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders

D Patel, MJ Kas, S Chattarji, B Buwalda - Behavioural brain research, 2019 - Elsevier
Exposure to severe or persistent social stress may lead to the development of psychiatric
disorders such as anxiety and depression. These mood disorders are associated with …

[HTML][HTML] Social hierarchy position in female mice is associated with plasma corticosterone levels and hypothalamic gene expression

CM Williamson, W Lee, AR DeCasien, A Lanham… - Scientific reports, 2019 - nature.com
Social hierarchies emerge when animals compete for access to resources such as food,
mates or physical space. Wild and laboratory male mice have been shown to develop linear …

The neural mechanisms of sexually dimorphic aggressive behaviors

K Hashikawa, Y Hashikawa, J Lischinsky, D Lin - Trends in Genetics, 2018 - cell.com
Aggression is a fundamental social behavior that is essential for competing for resources
and protecting oneself and families in both males and females. As a result of natural …