The effectiveness of many anticancer drugs depends on the creation of specific metabolites
that may alter their therapeutic or toxic properties. One significant route of biotransformation …

The search for new and efficient pharmaceuticals is a constant struggle for medicinal
chemists. New substances are needed in order to treat different pathologies affecting the …

The phrase “Let food be thy medicine…” means that food can be a form of medicine and
medicine can be a form of food; in other words, that the diet we eat can have a significant …

Nitro-fatty acids (NO2-FAs) are unsaturated fatty acid nitration products that exhibit anti-
inflammatory actions in experimental mouse models of autoimmune and allergic diseases …

Objective. Diabetes mellitus (DM) is a long‐life metabolic disorder, characterized by high
blood glucose levels. The hyperglycemic condition generally leads to irreversible nerve …

Background More than half of the colorectal cancer (CRC) patients will develop liver
metastasis that underlies the cancer mortality. In the hepatic tumor microenvironment, the …

Nitro fatty acids (NO 2-FAs) are endogenously generated lipid signaling mediators from
metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide …

Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and
mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of …

The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator
of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases …

Type II interferon may be one of the most important immunomodulatory factors involved in
the coordination of immune responses in vertebrates, but the efficacy of protein molecular …