Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …

Evidence is growing that the gut microbiota modulates the host response to
chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; …

Dynamic reprogramming of metabolism is essential for T cell effector function and memory
formation. However, the regulation of metabolism in exhausted CD8+ T (Tex) cells is poorly …

CD8+ T cells recognizing tumor-specific antigens are detected in cancer patients but are
dysfunctional. Here we developed a tamoxifen-inducible liver cancer mouse model with a …

Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-
blooded vertebrates for more than 600 million years of evolution. The fever response is …

In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and
highly efficient class of drugs. Several recently published studies emphasize the potential …

Weak and ineffective antitumor cytotoxic T lymphocyte (CTL) responses can be rescued by
immunomodulatory mAbs targeting PD-1 or CD137. Using Batf3−/− mice, which are …

Cancer cells can evade immune surveillance through the molecular interactions of immune
checkpoint proteins, including programmed death 1 (PD-1), PD-L1, and cytotoxic T …

Background The potential predictive role of programmed death-ligand-1 (PD-L1) expression
on tumor cells in the context of solid tumor treated with checkpoint inhibitors targeting the PD …