Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

Relapsing polychondritis (RP) is a rare inflammatory disease with significant individual
heterogeneity that involves systemic organs. The diagnosis of RP mainly depends on the …

Collagens are the most abundant components of the extracellular matrix (ECM) and many
types of soft tissues. Elastin is another major component of certain soft tissues, such as …

Energy metabolism and extracellular matrix (ECM) function together orchestrate and
maintain tissue organization, but crosstalk between these processes is poorly understood …

In the brain, the role of matrilin-3, an extracellular matrix component in cartilage, is unknown.
Here, we identify that matrilin-3 decreased in reactive astrocytes but was unchanged in …

Matrilins (MATN1, MATN2, MATN3 and MATN4) are adaptor proteins of the cartilage
extracellular matrix (ECM), which bridge the collagen II and proteoglycan networks. In …

Relapsing polychondritis is a chronic autoimmune inflammatory condition characterized by
recurrent episodes of inflammation at the level of cartilaginous structures and tissues rich in …

The secreted protein calcium-activated chloride channel regulator 1 (CLCA1) utilizes a von
Willebrand factor type A (VWA) domain to bind to and potentiate the calcium-activated …

Osteoarthritis (OA) is a leading cause of pain and disability worldwide in elderly people.
There is a critical need to develop novel therapeutic strategies that can effectively manage …

Bones are important constituents of the organ systems of the vertebrates providing body
support, physical protection for inner organs, movement facilitation, mineral storage and a …