The field of research on pain originating from various bone diseases is expanding rapidly,
with new mechanisms and targets asserting both peripheral and central sites of action. The …

Chronic pain represents one of the most serious worldwide medical problems, in terms of
both social and economic costs, often causing severe and intractable physical and …

Objectives The clinical utility of conventional IV opioids is limited by the occurrence of opioid‐
related adverse events. Oliceridine is a novel G protein–biased μ‐opioid receptor agonist …

Opioids, such as morphine and fentanyl, are widely used for the treatment of severe pain;
however, prolonged treatment with these drugs leads to the development of tolerance and …

The development of safe therapeutics to manage pain is of central interest for biomedical
applications. The fluorinated fentanyl derivative N-(3-fluoro-1-phenethylpiperidin-4-yl)-N …

Neuropathic pain (NP) refers to pain caused by primary or secondary damage or dysfunction
of the peripheral or central nervous system, which seriously affects the physical and mental …

Opioids such as morphine and oxycodone are analgesics frequently prescribed for the
treatment of moderate or severe pain. Unfortunately, these medications are associated with …

Background Pain management with conventional opioids can be challenging due to dose-
limiting adverse events (AEs), some of which may be related to the simultaneous activation …

Opioid use disorder (OUD) is a chronic brain disease which originates from long-term
neuroadaptations that develop after repeated opioid consumption and withdrawal episodes …

Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …