Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
B Apollonio, F Spada, N Petrov… - The Journal of …, 2023 - Am Soc Clin Investig
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has
highlighted the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) …
highlighted the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) …
[HTML][HTML] Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer
NH Ruddle - Current Opinion in Physiology, 2023 - Elsevier
High endothelial venules (HEVs), high walled cuboidal blood vessels, through their
expression of adhesion molecules and chemokines, allow the entrance of lymphoid cells …
expression of adhesion molecules and chemokines, allow the entrance of lymphoid cells …
Modeling the crosstalk between malignant B cells and their microenvironment in B-cell lymphomas: challenges and opportunities
B Brauge, E Dessauge, F Creusat, K Tarte - Frontiers in Immunology, 2023 - frontiersin.org
B-cell lymphomas are a group of heterogeneous neoplasms resulting from the clonal
expansion of mature B cells arrested at various stages of differentiation. Specifically, two …
expansion of mature B cells arrested at various stages of differentiation. Specifically, two …
Multi-scale characterization of tumor-draining lymph nodes in resectable lung cancer treated with neoadjuvant immune checkpoint inhibitors
H Yang, B Sun, W Ma, L Fan, K Xu, Y Jia, J Xu… - …, 2022 - thelancet.com
Background Regional lymph node (LN) acts as a pivotal organ for antitumor immunity.
Paradoxically, tumor-draining LNs (TDLNs) are usually the first site of tumor metastasis in …
Paradoxically, tumor-draining LNs (TDLNs) are usually the first site of tumor metastasis in …
Prevention of experimental autoimmune encephalomyelitis by targeting 6-sulfo sialyl Lewis X glycans involved in lymphocyte homing
Q Liu, W Xiong, S Obara, H Abo… - International …, 2024 - academic.oup.com
Lymphocyte homing to peripheral lymph nodes (PLN) is critical for immune surveillance.
However, autoimmune diseases such as multiple sclerosis (MS) can occur due to excessive …
However, autoimmune diseases such as multiple sclerosis (MS) can occur due to excessive …
Perspectives on vascular regulation of mechanisms controlling selective immune cell function in the tumor immune response
M Welsh - International Journal of Molecular Sciences, 2022 - mdpi.com
The vasculature plays a major role in regulating the tumor immune cell response although
the underlying mechanisms explaining such effects remain poorly understood. This review …
the underlying mechanisms explaining such effects remain poorly understood. This review …
Single-cell profiling identifies clinically relevant interactions between tumor associated macrophages and blood endothelial cells in diffuse large B cell lymphoma
J Ferrant, S Le Gallou, F Padonou, S Léonard, I Papa… - bioRxiv, 2022 - biorxiv.org
Diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) are the two most
common B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B …
common B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B …
Deciphering the role and the mechanism of B-cell Non-Hodgkin Lymphoma-derived small Extracellular Vesicles in modulating the phenotype of myeloid cells.
M Bordas - 2023 - archiv.ub.uni-heidelberg.de
Non-Hodgkin Lymphomas (NHL) represent one of the most common cancers worldwide.
Among the most common forms of NHL are found Chronic Lymphocytic Leukemia (CLL) …
Among the most common forms of NHL are found Chronic Lymphocytic Leukemia (CLL) …
[HTML][HTML] Analyses of murine lymph node endothelial cell subsets using single-cell RNA sequencing and spectral flow cytometry
L Menzel, M Zschummel, A Rehm - STAR protocols, 2022 - Elsevier
Blood endothelial cells (BECs) in lymph nodes are distinct stromal cells with a transcriptional
profile allowing fast and specific adaptation to the functional requirements. Here, we …
profile allowing fast and specific adaptation to the functional requirements. Here, we …
Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function
S Makris, Y Hari-Gupta, JA Cantoral-Rebordinos… - bioRxiv, 2022 - biorxiv.org
Lymph nodes are uniquely organised to form specialised niches for immune interactions.
Fibroblastic reticular cells (FRCs) are an essential stromal component of lymph nodes …
Fibroblastic reticular cells (FRCs) are an essential stromal component of lymph nodes …