Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …

Alzheimer's disease (AD) is characterized by cognitive impairment, progressive
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …

Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) …

Exosomes are small membranous vesicles of endocytic origin that are released by almost
every cell type. They exert versatile functions in intercellular communication important for …

J. Neurochem.(2008) 104, 1433–1439. Abstract Glycogen synthase kinase 3 (GSK3) is a
constitutively active, proline‐directed serine/threonine kinase that plays a part in a number of …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Lithium is a well-established therapeutic option for the acute and long-term management of
bipolar disorder and major depression. More recently, based on findings from translational …

Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …

Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has
become an important strategy for treating neurodegenerative and psychiatric disorders. The …

Neuronal inclusions comprised of the microtubule-associated protein tau are found in
numerous neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's …