When animal cells enter mitosis, they round up to become spherical. This shape change is
accompanied by changes in mechanical properties. Multiple studies using different …

Stem cells have the ability to self-renew and differentiate along multiple lineages, driving
tissue homeostasis and regeneration. Paradigms of unidirectional, hierarchical …

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …

Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue
architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the …

Cell polarization is linked to fate determination during asymmetric division of plant stem
cells, but the underlying molecular mechanisms remain unknown. In Arabidopsis …

Asymmetric cell divisions allow stem cells to balance proliferation and differentiation. During
embryogenesis, murine epidermis expands rapidly from a single layer of unspecified basal …

Tissue morphogenesis requires the coordinated regulation of cellular behavior, which
includes the orientation of cell division that defines the position of daughter cells in the …

Epithelia are polarized layers of adherent cells that are the building blocks for organ and
appendage structures throughout animals. To preserve tissue architecture and barrier …

The direction in which a cell divides is determined by the orientation of its mitotic spindle at
metaphase. Spindle orientation is therefore important for a wide range of developmental …

The development of complex stratified epithelial barriers in mammals is initiated from single-
layered epithelia. How stratification is initiated and fueled are still open questions. Previous …