Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Transcription activator-like effector nuclease (TALEN)-mediated genome modification has
been applied successfully to create transgenic animals in various species, such as mouse …

Surfactant, a lipoprotein complex, was originally described for its essential role in reducing
surface tension at the air–liquid interface of the lung; however, it is now recognized as being …

Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate
immunity. The proteins are host defense lectins, belonging to the collectin family which also …

The acute inflammatory airway response is characterized by a time-dependent onset
followed by active resolution. Emerging evidence suggests that epithelial cells of the …

Background Pulmonary surfactant protein D (SP-D) is considered as a candidate biomarker
for the functional integrity of the lung and for disease progression, which can be detected in …

The lung is continuously exposed to inhaled pollutants, microbes and allergens. Therefore,
the pulmonary immune system has to defend against harmful pathogens, while an …

Influenza A viruses (IAVs) remain a major health threat and a prime example of the
significance of innate immunity. Our understanding of innate immunity to IAV has grown …

Abstract Surfactant protein D (SP-D) plays important roles in innate host defense against
influenza A virus (IAV) infection, in part by modifying interactions with neutrophils. Human …