The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Pancreatic islets are endocrine organs that depend on their microvasculature to function.
Along with endothelial cells, pericytes comprise the islet microvascular network. These …

Abstract β-Cells depend on the islet basement membrane (BM). While some islet BM
components are produced by endothelial cells (ECs), the source of others remains …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

Secretion of glucagon from the pancreatic α-cells is conventionally seen as the first and most
important defense against hypoglycemia. Recent findings, however, show that α-cell signals …

The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and
deliver insulin and glucagon into the circulation. Long believed to be passive conduits of …

Since the generation of cell-type specific knockout models, the importance of inter-cellular
communication between neural, vascular, and microglial cells during neural development …

Glucose homeostasis depends on regulated insulin secretion from pancreatic β cells, which
acquire their mature phenotype postnatally. The functional maturation of β cells is regulated …