Dysfunction of mitochondrial complex I is associated with a wide spectrum of
neurodegenerative disorders, including Parkinson's disease (PD). In rodents, inhibition of …

Significance: Activation of mitochondrion-dependent programmed cell death (PCD)
pathways is instrumental to the demise of substantia nigra pars compacta dopaminergic …

Impairments in systematic and regional glucose metabolism exist in patients with
Parkinson's disease (PD) at every stage of the disease course, and such impairments are …

Background: CEP-1347 inhibits mixed lineage kinases that activate apoptotic pathways
implicated in the pathogenesis of Parkinson disease (PD). CEP-1347 enhances neuronal …

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease of the
brain. PD is characterized by motor and non-motor symptoms. The p75 neurotrophin …

Parkinson's disease is caused by a complex interplay of genetic and environmental factors.
Although a number of independent molecular pathways and processes have been …

Introduction: Apoptosis and autophagy impact cell death in multiple systems of the body.
Development of new therapeutic strategies that target these processes must address their …

purpose. Based on the evidence of an amplified production of reactive oxygen species
(ROS) during glaucomatous neurodegeneration, proteomic analysis was performed to …

Osteocyte apoptosis appears to play a key role in the mechanism by which osteoclastic
resorption activity targets bone for removal, because osteocyte apoptosis occurs in highly …

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-
apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing …