Background: p53 plays an important role in many areas of cellular physiology and biology,
ranging from cellular development and differentiation to cell cycle arrest and apoptosis …

The compound 1-methyl-4-phenylpyridinium (MPP) is a selective inhibitor of mitochondrial
complex I, and is widely used in model systems to elicit neurochemical alterations that may …

Parkinson's disease (PD) is morphologically characterized by progressive loss of neurons in
the substantia nigra pars compacta (SNpc) and other subcortical nuclei associated with …

Glyceraldehyde 3–phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme, which is
crucial for the breakdown of glucose to provide cellular energy. Over the past decade …

Parkinson's disease (PD) is a slowly progressive, age-related, neurodegenerative disorder.
The cause and mechanism of neuronal death have been elusive. However, recent genetic …

Multiple systemic atrophy (MSA) is a progressive, adult-onset neurodegenerative disorder of
undetermined aetiology characterized by a distinctive oligodendrogliopathy with argyrophilic …

Apoptotic cell death is implicated in both physiological and pathological processes. Since
many types of cancerous cells intrinsically evade apoptotic elimination, induction of …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the
cardinal features of tremor, bradykinesia, rigidity, and postural instability, in addition to other …

Caspases play a critical role in maintaining cellular homeostasis. Several types of cell death
are related to the activation of specific caspases. To investigate the role of specific cell death …

Mitochondrial dysfunction has long been associated with Parkinson's disease (PD). In
particular, complex I impairment and subsequent oxidative stress have been widely …