A highly complex network of intrinsic enteric neurons is required for the digestive and
homeostatic functions of the gut. Nevertheless, the genetic and molecular mechanisms that …

The development of the embryonic brain critically depends on successfully completing
cranial neural tube closure (NTC). Failure to properly close the neural tube results in …

Neural tube defects (NTDs) are a heterogeneous group of common severe congenital
anomalies which affect 1–2 infants per 1000 births. Most genetic and/or environmental …

Mammalian brain development requires coordination between neural precursor
proliferation, differentiation and cellular organization to create the intricate neuronal …

Non-canonical Wnt/planar cell polarity (PCP) signaling plays a primary role in the
convergent extension that drives neural tube closure and body axis elongation. PCP …

Hydrocephalus is a common finding in newborns. In most cases, it is caused by
intraventricular hemorrhage associated with prematurity, whereas in some patients the …

The neural tube is the first critically important structure that develops in the embryo. It serves
as the primordium of the central nervous system; therefore, the proper formation of the …

Inositols, a group of 6-carbon polyols, are highly bioactive molecules derived from diet and
endogenous synthesis. Inositols and their derivatives are involved in glucose and lipid …

Serum paraoxonase (PON1) is a key enzyme related to high‐density lipoprotein (HDL)‐
cholesterol particle. It can prevent the oxidation of low‐density lipoprotein (LDL) and HDL …

The molecular requirements for neural tube closure are complex. This is illustrated by the
occurrence of neural tube defects (NTDs) in many genetic mouse mutants, which implicate a …