During vertebrate axis extension, adjacent tissue layers undergo profound morphological
changes: within the neuroepithelium, neural tube closure and neural crest formation are …

Bioelectric signals, particularly transmembrane voltage potentials (V mem), play an
important role in large-scale patterning during embryonic development. Endogenous …

Background Neural tube defects (NTDs) is the most common birth defect of the central
nervous system (CNS) which causes the death of almost 88,000 people every year around …

Apical constriction is critical for epithelial morphogenesis, including neural tube formation.
Vertebrate apical constriction is induced by di‐phosphorylated myosin light chain (ppMLC) …

Although inositol dietary deficiency in the general population has not been demonstrated at
the serum level, several findings are emerging regarding the impact of inositol …

Extensive studies that have sought causative mutation (s) for neural tube defects (NTDs)
have yielded limited positive findings to date. One possible reason for this is that many …

Microtubules (MTs) are key cellular components, long known to participate in morphogenetic
events that shape the developing embryo. However, the links between the cellular functions …

Introduction Primary and secondary neurulation are the two known processes that form the
central neuraxis of vertebrates. Human phenotypes of neural tube defects (NTDs) mostly fall …

Neural tube defects (NTDs) are among the most common and disabling fetal congenital
defects. Organochlorine pesticides (OCPs) are ubiquitous in the environment. In this study …

Diverse cell types in the central nervous system (CNS) are generated by a relatively small
pool of neural stem cells during early development. Spatial and temporal regulation of stem …