Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

Although single-cell and spatial sequencing methods enable simultaneous measurement of
more than one biological modality, no technology can capture all modalities within the same …

The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …

The BCL2 inhibitor venetoclax has recently emerged as an important component of acute
myeloid leukemia (AML) therapy. Notably, use of this agent has revealed a previously …

Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of
immunological defense against inhaled or ingested pathogens. We generated an atlas of …

Background Third-generation chimeric antigen receptor (CAR)-engineered T cells (CARTs)
might improve clinical outcome of patients with B cell malignancies. This is the first report on …

In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors
(TKIs), especially in the absence of kinase domain mutations in BCR-ABL1, is poorly …