NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of
ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in …

Abstract Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of
cellular pathways that are fundamental for brain function, including neurotransmitter …

Traumatic brain injury (TBI) consists of acute and long-term pathophysiological sequelae
that ultimately lead to cognitive and motor function deficits, with age being a critical risk …

Recent data suggest mechanistic links among perturbed iron homeostasis, oxidative stress,
and misfolded protein aggregation in neurodegenerative diseases. Iron overload and …

The discovery of the role of autophagy, particularly the selective form like ferritinophagy, in
promoting cells to undergo ferroptosis has inspired us to investigate functional connections …

Iron, the most abundant metal in human brain, is an essential microelement that regulates
numerous cellular mechanisms. Some key physiological roles of iron include oxidative …

Aging leads to gray and white matter decline but their causation remains unclear. We
explored two classes of models of age and dementia risk related brain changes. The first …

Parkinson's disease (PD) is a complicated and incapacitating neurodegenerative malady
that emanates following the dopaminergic (DArgic) nerve cell deprivation in the substantia …

Purpose To examine the relationship between apolipoprotein E gene (APOE) mutation
status and iron accumulation in the deep gray matter of subjects with cognitive symptoms …

Alpha-synuclein has long been studied due to its involvement in the progression of
Parkinson's disease (PD), a common neurodegenerative disorder, although a consensus on …