Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges
Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent
slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a …
slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a …
Food for thought: formulating away the food effect–a PEARRL review
Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …
[HTML][HTML] Development of nanocrystal compressed minitablets for chronotherapeutic drug delivery
The present work aimed to develop a chronotherapeutic system of valsartan (VS) using
nanocrystal formulation to improve dissolution. VS nanocrystals (VS-NC) were fabricated …
nanocrystal formulation to improve dissolution. VS nanocrystals (VS-NC) were fabricated …
Oral formulation strategies to improve the bioavailability and mitigate the food effect of abiraterone acetate
Abiraterone acetate, marketed as Zytiga®, is an antiandrogen medication used in the
treatment of prostate cancer. Abiraterone acetate is a BCS Class IV compound associated …
treatment of prostate cancer. Abiraterone acetate is a BCS Class IV compound associated …
A safety, tolerability, and pharmacokinetic study of a novel simvastatin silica-lipid hybrid formulation in healthy male participants
Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of
major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is …
major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is …
Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability
Self-emulsifying drug delivery systems (SEDDS) have been widely employed to improve the
oral bioavailability of poorly soluble drugs. In the past few years, SEDDS were extensively …
oral bioavailability of poorly soluble drugs. In the past few years, SEDDS were extensively …
[HTML][HTML] Fast-fed variability: Insights into drug delivery, molecular manifestations, and regulatory aspects
N Rangaraj, S Sampathi, V Junnuthula, P Kolimi… - Pharmaceutics, 2022 - mdpi.com
Among various drug administration routes, oral drug delivery is preferred and is considered
patient-friendly; hence, most of the marketed drugs are available as conventional tablets or …
patient-friendly; hence, most of the marketed drugs are available as conventional tablets or …
Self-microemulsifying drug-delivery system: ongoing challenges and future ahead
Self-microemulsifying drug-delivery system (SMEDDS) can be defined as an isotropic
system containing lipid and surfactant as well as cosurfactant that develop an emulsion in …
system containing lipid and surfactant as well as cosurfactant that develop an emulsion in …
Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry
TR Meola, HB Schultz, KF Peressin… - European Journal of …, 2020 - Elsevier
Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system
under investigation for their aptitude to enhance the oral bioavailability of poorly water …
under investigation for their aptitude to enhance the oral bioavailability of poorly water …
Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and …
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …