Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges

P Joyce, TJ Dening, TR Meola, HB Schultz… - Advanced drug delivery …, 2019 - Elsevier
Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent
slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a …

Food for thought: formulating away the food effect–a PEARRL review

JP O'Shea, R Holm, CM O'Driscoll… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …

[HTML][HTML] Development of nanocrystal compressed minitablets for chronotherapeutic drug delivery

N Sreeharsha, NR Naveen, P Anitha, PS Goudanavar… - Pharmaceuticals, 2022 - mdpi.com
The present work aimed to develop a chronotherapeutic system of valsartan (VS) using
nanocrystal formulation to improve dissolution. VS nanocrystals (VS-NC) were fabricated …

Oral formulation strategies to improve the bioavailability and mitigate the food effect of abiraterone acetate

HB Schultz, TR Meola, N Thomas… - International journal of …, 2020 - Elsevier
Abiraterone acetate, marketed as Zytiga®, is an antiandrogen medication used in the
treatment of prostate cancer. Abiraterone acetate is a BCS Class IV compound associated …

A safety, tolerability, and pharmacokinetic study of a novel simvastatin silica-lipid hybrid formulation in healthy male participants

TR Meola, AY Abuhelwa, P Joyce, P Clifton… - Drug delivery and …, 2021 - Springer
Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of
major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is …

Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability

K AboulFotouh, AA Allam, M El-Badry… - Colloids and Surfaces B …, 2018 - Elsevier
Self-emulsifying drug delivery systems (SEDDS) have been widely employed to improve the
oral bioavailability of poorly soluble drugs. In the past few years, SEDDS were extensively …

[HTML][HTML] Fast-fed variability: Insights into drug delivery, molecular manifestations, and regulatory aspects

N Rangaraj, S Sampathi, V Junnuthula, P Kolimi… - Pharmaceutics, 2022 - mdpi.com
Among various drug administration routes, oral drug delivery is preferred and is considered
patient-friendly; hence, most of the marketed drugs are available as conventional tablets or …

Self-microemulsifying drug-delivery system: ongoing challenges and future ahead

K Rajpoot, M Tekade, V Pandey, SH Nagaraja… - Drug delivery …, 2020 - Elsevier
Self-microemulsifying drug-delivery system (SMEDDS) can be defined as an isotropic
system containing lipid and surfactant as well as cosurfactant that develop an emulsion in …

Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry

TR Meola, HB Schultz, KF Peressin… - European Journal of …, 2020 - Elsevier
Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system
under investigation for their aptitude to enhance the oral bioavailability of poorly water …

Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and …

N Akhtar, SAA Mohammed, RA Khan, M Yusuf… - Journal of Drug Delivery …, 2020 - Elsevier
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …