The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …

Pancreatic endocrine neoplasms (PETs) are uncommon tumors with an annual incidence
less than 1 per 100,000 persons per year in the general population. PETs that produce …

Gene targeting in embryonic stem cells has become the principal technology for
manipulation of the mouse genome, offering unrivalled accuracy in allele design and access …

In development, tissue regeneration or certain diseases, angiogenic growth leads to the
expansion of blood vessels and the lymphatic vasculature. This involves endothelial cell …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

The sequence of the mouse genome is a key informational tool for understanding the
contents of the human genome and a key experimental tool for biomedical research. Here …

Slow, controlled breathing has been used for centuries to promote mental calming, and it is
used clinically to suppress excessive arousal such as panic attacks. However, the …

The multi-component mechanistic target of rapamycin complex 1 (mTORC1) kinase is the
central node of a mammalian pathway that coordinates cell growth with the availability of …

We report on a microfluidic particle-separation device that makes use of the asymmetric
bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on …

Comparison of genomic DNA sequences from human and mouse revealed a new
apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized …