The coiled-coil domain-containing (CCDC) proteins have been implicated in a variety of
physiological and pathological processes. Their functional roles vary from their interaction …

HIV-associated neurocognitive disorders (HAND) are the result of the activity of HIV-1 within
the central nervous system (CNS). While the introduction of antiretroviral therapy (ART) has …

Subversion of the host cell cycle to facilitate viral replication is a common feature of
coronavirus infections. Coronavirus nucleocapsid (N) protein can modulate the host cell …

HIV-1 remains a global health crisis, highlighting the need to identify new targets for
therapies. Here, given the disproportionate HIV-1 burden and marked human genome …

HIV-1 must replicate in cells that are equipped to defend themselves from infection through
intracellular innate immune systems. HIV-1 evades innate immune sensing through …

The latent reservoir for HIV-1 in resting CD4+ T cells persists despite antiretroviral therapy
as a barrier to cure. The antigendriven proliferation of infected cells is a major mechanism of …

Emerging evidence indicates that HIV-1 hijacks host DNA damage repair (DDR) pathways to
facilitate multiple facets of virus replication. Canonically, HIV-1 engages proviral DDR …

Accessory proteins are a key feature that distinguishes primate immunodeficiency viruses
such as human immunodeficiency virus type I (HIV-1) from other retroviruses. A prime …

A significant number of patients infected with HIV-1 suffer from HIV-associated
neurocognitive disorders (HAND) such as spatial memory impairments and learning …

HIV infects several cell types in the body, including CD4+ T cells and macrophages. Here
we review the role of macrophages in HIV infection and describe complex interactions …