Background Drug development is currently hampered by high attrition rates; many
developed treatments fail during clinical testing. Part of the attrition may be due to low …

Hereditary pancreatitis has recently emerged as an important pancreatic disease. Although
relatively rare, this genetic disorder has provided major breakthroughs in our understanding …

The value of the Acute Physiology and Chronic Health Enquiry (APACHE-II) score, the
Simplified Acute Physiology score, and the Medical Research Council (MRC) sepsis score …

BACKGROUND The pharmacological inhibition of exocrine pancreatic secretion with the
somatostatin analogue octreotide has been advocated as a specific treatment of acute …

Trypsinogen activation can be quantified by measurement of released activation peptides
(TAP assay). TAP assay in urine was performed on admission for 55 patients with acute …

Background: A multicenter controlled study was performed to evaluate the effect of high
doses of the low molecular weight protease inhibitor gabexate mesilate on mortality and …

Little is known about exocrine pancreatic secretory function in patients with acute
pancreatitis, in particular during the early phase of the disease. Therefore, this study …

The care of patients with severe acute pancreatitis is complex. Although numerous medical
therapies have been proposed, few interventions have been shown to be of benefit in …

Background: Autodigestion of the pancreas, secondary to the activation of digestive
enzymes, is the pathogenetic mechanism of acute pancreatitis (AP). Aim: Clinical trials in …

Acute pancreatitis (AP) is a common and potentially lethal acute inflammatory process with a
highly variable clinical course. It is still unclear why some patients progress to organ failure …