Background: Although high-risk mutations in identified major susceptibility genes (DNA
mismatch repair genes and MUTYH) account for some familial aggregation of colorectal …

Background The purpose of this study was to estimate precise age-specific tubo-ovarian
carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C …

In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic
counselling purposes, it is important to allow for the fact that other breast cancer …

Advances in genomics have near-term impact on diagnosis and management of monogenic
disorders. For common complex diseases, the use of genomic information from multiple loci …

We used data from a population based series of breast cancer patients to investigate the
genetic models that can best explain familial breast cancer not due to the BRCA1 and …

Susceptibility to breast cancer is likely to be the result of susceptibility alleles in many
different genes. In particular, one segregation analysis of breast cancer suggested that …

Rare pathogenic variants in known breast cancer-susceptibility genes and known common
susceptibility variants do not fully explain the familial aggregation of breast cancer. To …

Introduction Mutations in BRCA1 and BRCA2 confer high risks of breast cancer and ovarian
cancer. The risk prediction algorithm BOADICEA (Breast and Ovarian Analysis of Disease …

Background Although BRCA1 and BRCA2 mutations account for only∼ 27% of the familial
aggregation of ovarian cancer (OvC), no OvC risk prediction model currently exists that …

Genome wide association studies have identified several single nucleotide polymorphisms
(SNPs) that are independently associated with small increments in risk of prostate cancer …