Originally proposed one decade ago, the idea of engineering proteins outside the
immunoglobulin family for novel binding functions has evolved as a powerful technology …

The global antibody market has grown exponentially due to increasing applications in
research, diagnostics and therapy. Antibodies are present in complex matrices (eg serum …

Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites
on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long …

Phage display, the presentation of (poly) peptides as fusions to capsid proteins on the
surface of bacterial viruses, celebrates its 25th birthday in 2010. The technique, coupled with …

Many successful, recent therapies for life-threatening diseases such as cancer and
rheumatoid arthritis are based on the recognition between native or genetically engineered …

Antibodies continue to be extremely utilized entities in myriad applications including basic
research, imaging, targeted delivery, chromatography, diagnostics, and therapeutics. At …

The demand for recombinant therapeutic antibodies and Fc-fusion proteins is expected to
increase in the years to come. Hence, extensive efforts are concentrated on improving the …

Mixed-mode chromatography is a chromatographic method that utilizes more than one form
of interactions between the stationary phase and the solutes in a feed stream. Compared …

Chromatographic resins of a family of linear Fc-binding hexamer peptides (HWRGWV,
HYFKFD, and HFRRHL) exhibited the ability to selectively adsorb and isolate human IgG …

Most will agree that one major achievement in the bio-separation techniques is affinity
chromatography. This coined terminology covers a myriad of separation approaches that …