Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

AB Kunnumakkara, D Bordoloi… - British journal of …, 2017 - Wiley Online Library
Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is
chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 …

Polyphenols from food and natural products: Neuroprotection and safety

RFM Silva, L Pogačnik - Antioxidants, 2020 - mdpi.com
Polyphenols are naturally occurring micronutrients that are present in many food sources.
Besides being potent antioxidants, these molecules may also possess anti-inflammatory …

Regulation of immune function by polyphenols

S Ding, H Jiang, J Fang - Journal of immunology research, 2018 - Wiley Online Library
Immune dysfunction is caused by various factors, including changes in relevant immune
regulators and environmental stress. Immune system imbalance leads to a variety of …

Is curcumin bioavailability a problem in humans: Lessons from clinical trials

AB Kunnumakkara, C Harsha, K Banik… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Since ancient times, turmeric has been used in several folklore remedies
against various ailments. The principal component of turmeric is curcumin and its efficacy …

Polyphenols in the treatment of autoimmune diseases

H Khan, A Sureda, T Belwal, S Çetinkaya, İ Süntar… - Autoimmunity …, 2019 - Elsevier
In addition to protecting body from infections and diseases, the immune system produces
auto-antibodies that can cause complex autoimmune disorders, such as Type I diabetes …

Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

M Pourmadadi, P Abbasi, MM Eshaghi… - Journal of Drug Delivery …, 2022 - Elsevier
Throughout the world, cancer is one of the main causes of mortality, threatening the public
health in many countries. As a result, cancer therapy researchers are paying increasing …

[HTML][HTML] Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes

PS Baxter, GE Hardingham - Free Radical Biology and Medicine, 2016 - Elsevier
The human brain generally remains structurally and functionally sound for many decades,
despite the post-mitotic and non-regenerative nature of neurons. This is testament to the …

Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results

N Mut-Salud, PJ Álvarez, JM Garrido… - Oxidative Medicine …, 2016 - Wiley Online Library
The role of the induction of oxidative stress as the mechanism of action of many antitumor
drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may …

The role of curcumin in the modulation of ageing

A Bielak-Zmijewska, W Grabowska, A Ciolko… - International journal of …, 2019 - mdpi.com
It is believed that postponing ageing is more effective and less expensive than the treatment
of particular age-related diseases. Compounds which could delay symptoms of ageing …