One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

This review focuses on the biomedical application of mesoporous silica nanoparticles
(MSNs), mainly focusing on the therapeutic application of MSNs for cancer treatment and …

Blind mole rats (BMRs) are small rodents, characterized by an exceptionally long lifespan (>
21 years) and resistance to both spontaneous and induced tumorigenesis. Here we report …

Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Background: Since disulfiram's discovery in the 1940s and its FDA approval for alcohol use
disorder, other indications have been investigated. This review describes potential clinical …

Human cervical cancer is the fourth most common malignancy among women worldwide,
and it is expected to result in 460,000 deaths per year by 2040. Moreover, patients with …

Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Repurposing approved non-antitumor drugs is a promising and affordable strategy in drug
discovery to identify new therapeutic uses different from the original medical indication that …

Microglia are the resident immune cells of the central nervous system (CNS). It is well
established that microglia are activated and polarized to acquire different inflammatory …

Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …