Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

Imbalanced regulation of reactive oxygen species (ROS) and antioxidant factors in cells is
known as “oxidative stress (OS)”. OS regulates key cellular physiological responses through …

The present study was designed to evaluate the effects of matrine (MAT) on D‐galactose‐(D‐
gal‐) induced aging and relative mechanism. Vitamin E at the dose of 100 mg/kg was used …

Background Senescent astrocytes have been implicated in the aging brain and
neurodegenerative disorders, including Parkinson's disease (PD). Astragaloside IV (AS-IV) …

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by
several pathological features, including selective neuronal loss, aggregation of specific …

Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

When an individual is under stress, the undesired effect on the brain often exceeds
expectations. Additionally, when stress persists for a long time, it can trigger serious health …

As the global population ages, the prevalence of Parkinson's disease (PD) is steadily on the
rise. PD demonstrates chronic and progressive characteristics, and many cases can …

Aging is a natural phenomenon characterized by accumulation of cellular damage and
debris. Oxidative stress, cellular senescence, sustained inflammation, and DNA damage are …