[HTML][HTML] Monkeypox: epidemiology, pathogenesis, treatment and prevention
Y Huang, L Mu, W Wang - Signal Transduction and Targeted Therapy, 2022 - nature.com
Monkeypox is a zoonotic disease that was once endemic in west and central Africa caused
by monkeypox virus. However, cases recently have been confirmed in many nonendemic …
by monkeypox virus. However, cases recently have been confirmed in many nonendemic …
The development and approval of tecoviromat (TPOXX®), the first antiviral against smallpox
M Merchlinsky, A Albright, V Olson, H Schiltz… - Antiviral research, 2019 - Elsevier
The classification of smallpox by the US Centers for Disease Control and Prevention (CDC)
as a Category A Bioterrorism threat agent has resulted in the US Government investing …
as a Category A Bioterrorism threat agent has resulted in the US Government investing …
[HTML][HTML] IMVAMUNE® and ACAM2000® Provide Different Protection against Disease When Administered Postexposure in an Intranasal Monkeypox Challenge …
MS Keckler, JS Salzer, N Patel, MB Townsend… - Vaccines, 2020 - mdpi.com
The protection provided by smallpox vaccines when used after exposure to Orthopoxviruses
is poorly understood. Postexposu re administration of 1st generation smallpox vaccines was …
is poorly understood. Postexposu re administration of 1st generation smallpox vaccines was …
Drug development against smallpox: present and future
D Delaune, F Iseni - Antimicrobial Agents and Chemotherapy, 2020 - Am Soc Microbiol
Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a
major threat to humans due to its possible use as a bioterrorism agent. For many years, the …
major threat to humans due to its possible use as a bioterrorism agent. For many years, the …
Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses
DF Florescu, MA Keck - Expert review of anti-infective therapy, 2014 - Taylor & Francis
CMX001 (hexadecyloxypropyl-cidofovir, Brincidofovir) is a broad spectrum, lipid conjugate
of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate …
of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate …
Development of CMX001 for the treatment of poxvirus infections
R Lanier, L Trost, T Tippin, B Lampert, A Robertson… - Viruses, 2010 - mdpi.com
CMX001 (phosphonic acid,[[(S)-2-(4-amino-2-oxo-1 (2H)-pyrimidinyl)-1-(hydroxymethyl)
ethoxy] methyl] mono [3-(hexadecyloxy) propyl] ester) is a lipid conjugate of the acyclic …
ethoxy] methyl] mono [3-(hexadecyloxy) propyl] ester) is a lipid conjugate of the acyclic …
A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge
S Parker, J D'Angelo, RM Buller, DF Smee, J Lantto… - Antiviral Research, 2021 - Elsevier
Orthopoxviruses such as variola and monkeypox viruses continue to threaten the human
population. Monkeypox virus is endemic in central and western Africa and outbreaks have …
population. Monkeypox virus is endemic in central and western Africa and outbreaks have …
Highlights in antiviral drug research: antivirals at the horizon
ED Clercq - Medicinal Research Reviews, 2013 - Wiley Online Library
This review highlights ten “hot topics” in current antiviral research:(i) new nucleoside
derivatives (ie, PSI‐352938) showing high potential as a direct antiviral against hepatitis C …
derivatives (ie, PSI‐352938) showing high potential as a direct antiviral against hepatitis C …
[HTML][HTML] The efficacy and pharmacokinetics of brincidofovir for the treatment of lethal rabbitpox virus infection: a model of smallpox disease
LC Trost, ML Rose, J Khouri, L Keilholz, J Long… - Antiviral research, 2015 - Elsevier
Brincidofovir (BCV) has broad-spectrum in vitro activity against dsDNA viruses, including
smallpox, and is being developed as a treatment for smallpox as well as infections caused …
smallpox, and is being developed as a treatment for smallpox as well as infections caused …
Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox–an animal model of smallpox
S Parker, NG Chen, S Foster, H Hartzler, E Hembrador… - Antiviral research, 2012 - Elsevier
The human population is currently faced with the potential use of natural or recombinant
variola and monkeypox viruses as biological weapons. Furthermore, the emergence of …
variola and monkeypox viruses as biological weapons. Furthermore, the emergence of …