Arterial occlusive disease is the leading cause of death in Western countries. Core
contemporary therapies for this disease include angioplasties, stents, endarterectomies and …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction
upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT …

The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have
been extensively reviewed since its discovery over 40 years ago. Here, we will describe …

In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can
end up in respiratory failure. Even though the main fibrotic disease affecting the lung is …

Shear stress generated by urinary fluid flow is an important regulator of renal function. Its
dysregulation is observed in various chronic and acute kidney diseases. Previously, we …

High extracellular matrix stiffness is a prominent feature of malignant tumors associated with
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …

The physical microenvironment of cancer is characterized by elevated stiffness and tissue
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …

Renal fibrosis is the most common pathological manifestation of a wide variety of chronic
kidney disease. Increased extracellular matrix (ECM) secretion and enhanced …

Background: The Hippo-YAP (yes-associated protein) signaling pathway is modulated in
response to various environmental cues. Activation of YAP in vascular smooth muscle cells …