Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion,
intravasation, circulation, arrest/adhesion and extravasation require specific mechanical …

The contribution of the epicardium, the outermost layer of the heart, to cardiac regeneration
has remained controversial due to a lack of suitable analytical tools. By combining genetic …

Hypertrophic scarring (HTS) is a major source of morbidity after cutaneous injury. Recent
studies indicate that mechanical force significantly impacts wound healing and skin …

Mesenchymal cells in the lung are crucial during development, but also contribute to the
pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most …

Disruption of the extracellular matrix (ECM) and an accumulation of fibrotic lesions within
tissues are two of the distinctive hallmarks of the aging process. Tissue fibroblasts are …

Background: The Hippo-YAP (yes-associated protein) signaling pathway is modulated in
response to various environmental cues. Activation of YAP in vascular smooth muscle cells …

Fibroblast to myofibroblast transdifferentiation mediates numerous fibrotic disorders, such as
idiopathic pulmonary fibrosis (IPF). We have previously demonstrated that non-muscle …

Extracellular vesicles (EVs) are implicated as promising therapeutics and drug delivery
vehicles in various diseases. However, successful clinical translation will depend on the …

Breast cancer is characterized by physical changes that occur in the tumor
microenvironment throughout growth and metastasis of tumors. Extracellular matrix stiffness …