Multidrug resistance is a leading concern in public health. It describes a complex phenotype
whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic …

Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide.
It is usually diagnosed in an advanced stage and is characterized by a high intrinsic drug …

Chemotherapeutics remain the first choice for advanced gastric cancers (GCs). However,
drug resistance and unavoidable severe toxicity lead to chemotherapy failure and poor …

Enabled by a plethora of new technologies, research in membrane transporters has
exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent …

Abstract Adjuvant chemotherapy with 5-fluorouracil (5-FU) does not improve survival of
patients suffering from a form of colorectal cancer (CRC) characterized by high level of …

ABSTRACT ATP-binding cassette (ABC) transporters represent one of the largest protein
superfamilies. Functionally diverse, ABC transporters have been implicated in many aspects …

As the most common primary tumour of the central nervous system, gliomas have a high
recurrence rate after surgical resection and are resistant to chemotherapy, particularly high …

Combatting the ever-increasing threat from invasive fungal pathogens faces numerous
fundamental challenges, including constant human exposure to large reservoirs of species …

Saprolegnia ferax (S. ferax) is one of the most highly pathogenic oomycetes species in
freshwater aquatic environments causing serious saprolegniosis. Linalool is a kind of …

Candida auris is an emerging multidrug-resistant human fungal pathogen often refractory to
treatment by all classes of antifungal drugs. Amphotericin B (AmB) is a fungicidal drug that …