The lipocalin apolipoprotein D functional portrait: a systematic review

D Sanchez, MD Ganfornina - Frontiers in Physiology, 2021 - frontiersin.org
Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Among
other features, regulation of its expression in a wide variety of disease conditions in humans …

Recent developments of neuroprotective agents for degenerative retinal disorders

K Ou, Y Li, L Liu, H Li, K Cox, J Wu, J Liu… - Neural Regeneration …, 2022 - journals.lww.com
Retinal degeneration is a debilitating ocular complication characterized by the progressive
loss of photoreceptors and other retinal neurons, which are caused by a group of retinal …

[HTML][HTML] The association of physical activity with glaucoma and related traits in the UK Biobank

KM Madjedi, KV Stuart, SYL Chua, PY Ramulu… - Ophthalmology, 2023 - Elsevier
Purpose To examine the association of physical activity (PA) with glaucoma and related
traits, to assess whether genetic predisposition to glaucoma modified these associations …

Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model

S Reinehr, JD Doerner, AM Mueller-Buehl… - Frontiers in Cellular …, 2021 - frontiersin.org
Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion
cells (RGCs) and optic nerve axons. An activation of the complement system seems to …

The role of complement dysregulation in glaucoma

C Hoppe, M Gregory-Ksander - International Journal of Molecular …, 2024 - mdpi.com
Glaucoma is a progressive neurodegenerative disease characterized by damage to the
optic nerve that results in irreversible vision loss. While the exact pathology of glaucoma is …

Antibody and protein profiles in glaucoma: screening of biomarkers and identification of signaling pathways

N Auler, H Tonner, N Pfeiffer, FH Grus - Biology, 2021 - mdpi.com
Simple Summary Glaucoma is a chronic eye disease that is one of the leading causes of
blindness worldwide. Currently, the only therapeutic option is to lower intraocular pressure …

Proteome alterations in the aqueous humor reflect structural and functional phenotypes in patients with advanced normal-tension glaucoma

SH Lee, JH Jung, TK Park, CE Moon, K Han, J Lee… - Scientific reports, 2022 - nature.com
Previous reports have shown possible association between altered protein levels in
aqueous humor (AH) and normal-tension glaucoma (NTG), but the underlying pathogenetic …

Preservation of optic nerve structure by complement inhibition in experimental glaucoma

CJ Gassel, S Reinehr, SC Gomes, HB Dick… - Cell and tissue …, 2020 - Springer
Glaucoma is characterized by a progressive damage of the retina and the optic nerve.
Despite a huge research interest, the exact pathomechanisms are still unknown. In the …

Proteome characterization of glaucoma aqueous humor

X Liu, X Liu, Y Wang, H Sun, Z Guo, X Tang, J Li… - Molecular & Cellular …, 2021 - ASBMB
Glaucoma is the leading cause of irreversible blindness worldwide. The proteome
characterization of glaucoma is not clearly understood. A total of 175 subjects, including 57 …

Advances in aqueous humor proteomics for biomarker discovery and disease mechanisms exploration: a spotlight on primary open angle glaucoma

VM Beutgen, J Graumann - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
Altered protein levels in the aqueous humor (AH) may be a valuable source of novel
biomarkers in neurodegenerative retinal disease. The proximity of this body fluid to the …