Aptamer–protein interactions: from regulation to biomolecular detection

C Ji, J Wei, L Zhang, X Hou, J Tan, Q Yuan… - Chemical …, 2023 - ACS Publications
Serving as the basis of cell life, interactions between nucleic acids and proteins play
essential roles in fundamental cellular processes. Aptamers are unique single-stranded …

Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment

S Qi, N Duan, IM Khan, X Dong, Y Zhang, S Wu… - Biotechnology …, 2022 - Elsevier
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized
libraries, presenting high affinity and specificity toward targets with similar to antibodies …

High‐affinity dimeric aptamers enable the rapid electrochemical detection of wild‐type and B. 1.1. 7 SARS‐CoV‐2 in unprocessed saliva

Z Zhang, R Pandey, J Li, J Gu, D White… - Angewandte …, 2021 - Wiley Online Library
We report a simple and rapid saliva‐based SARS‐CoV‐2 antigen test that utilizes a newly
developed dimeric DNA aptamer, denoted as DSA1N5, that specifically recognizes the spike …

Aptamer-based targeted protein degradation

Y Liu, X Qian, C Ran, L Li, T Fu, D Su, S Xie, W Tan - ACS nano, 2023 - ACS Publications
The selective removal of misfolded, aggregated, or aberrantly overexpressed protein plays
an essential role in maintaining protein-dominated biological processes. In parallel, the …

Aptamer-targeted photodynamic platforms for tumor therapy

J Yan, T Gao, Z Lu, J Yin, Y Zhang… - ACS applied materials & …, 2021 - ACS Publications
Achieving controlled and accurate delivery of photosensitizers (PSs) into tumor sites is a
major challenge in conventional photodynamic therapy (PDT). Aptamer is a short …

A HCR based multivalent aptamer amplifier for ultrasensitive detection of Salmonella

M Sun, N Ma, H Shi, LZ Cheong, W Yang… - Sensors and Actuators B …, 2023 - Elsevier
Aptamer holds great promise as an alternative recognition element for foodborne pathogens
detection because of its superior structural features. However, its application is still limited by …

Multivalent duplexed-aptamer networks regulated a CRISPR-Cas12a system for circulating tumor cell detection

Z Lv, Q Wang, M Yang - Analytical Chemistry, 2021 - ACS Publications
Although circulating tumor cells (CTCs) have great potential to act as the mini-invasive liquid
biopsy cancer biomarker, a rapid and sensitive CTC detection method remains lacking …

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

L Chen, S Zhang, Y Duan, X Song, M Chang… - Chemical Society …, 2024 - pubs.rsc.org
The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

Surface functionalization of gold nanoparticles for targeting the tumor microenvironment to improve antitumor efficiency

KF Tan, LLA In, P Vijayaraj Kumar - ACS applied bio materials, 2023 - ACS Publications
Gold nanoparticles (AuNPs) have undergone significant research for their use in the
treatment of cancer. Numerous researchers have established their potent antitumor …

Cell Surface Engineering Tools for Programming Living Assemblies

J Almeida‐Pinto, MR Lagarto, P Lavrador… - Advanced …, 2023 - Wiley Online Library
Breakthroughs in precision cell surface engineering tools are supporting the rapid
development of programmable living assemblies with valuable features for tackling complex …