Simulating progressive intramural damage leading to aortic dissection using DeepONet: an operator–regression neural network

M Yin, E Ban, BV Rego, E Zhang… - Journal of the …, 2022 - royalsocietypublishing.org
Aortic dissection progresses mainly via delamination of the medial layer of the wall.
Notwithstanding the complexity of this process, insight has been gleaned by studying in vitro …

[HTML][HTML] Imaging techniques for aortic aneurysms and dissections in mice: comparisons of ex vivo, in situ, and ultrasound approaches

S Ito, HS Lu, A Daugherty, H Sawada - Biomolecules, 2022 - mdpi.com
Aortic aneurysms and dissections are life-threatening conditions that have a high risk for
lethal bleeding and organ malperfusion. Many studies have investigated the molecular basis …

[HTML][HTML] MicroBundleCompute: Automated segmentation, tracking, and analysis of subdomain deformation in cardiac microbundles

H Kobeissi, J Jilberto, MÇ Karakan, X Gao… - Plos one, 2024 - journals.plos.org
Advancing human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM)
technology will lead to significant progress ranging from disease modeling, to drug …

Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement

D Weiss, M Latorre, BV Rego, C Cavinato, BJ Tanski… - Acta biomaterialia, 2021 - Elsevier
Abdominal aortic aneurysms (AAAs) are characterized histopathologically by compromised
elastic fiber integrity, lost smooth muscle cells or their function, and remodeled collagen. We …

[HTML][HTML] General finite-element framework of the virtual fields method in nonlinear elasticity

Y Mei, J Liu, X Guo, B Zimmerman, TD Nguyen… - Journal of Elasticity, 2021 - Springer
This paper presents a method to derive the virtual fields for identifying constitutive model
parameters using the Virtual Fields Method (VFM). The VFM is an approach to identify …

Exploring the potential of transfer learning for metamodels of heterogeneous material deformation

E Lejeune, B Zhao - Journal of the Mechanical Behavior of Biomedical …, 2021 - Elsevier
From the nano-scale to the macro-scale, biological tissue is spatially heterogeneous. Even
when tissue behavior is well understood, the exact subject specific spatial distribution of …

Uncertainty quantification in subject‐specific estimation of local vessel mechanical properties

BV Rego, D Weiss, MR Bersi… - International journal for …, 2021 - Wiley Online Library
Quantitative estimation of local mechanical properties remains critically important in the
ongoing effort to elucidate how blood vessels establish, maintain, or lose mechanical …

FEniCS implementation of the Virtual Fields Method (VFM) for nonhomogeneous hyperelastic identification

J Deng, X Guo, Y Mei, S Avril - Advances in Engineering Software, 2023 - Elsevier
It is of great significance to identify the nonhomogeneous distribution of material properties
in human tissues for different clinical and medical applications. This leads to the requirement …

Evolving Mural Defects, Dilatation, and Biomechanical Dysfunction in Angiotensin II–Induced Thoracic Aortopathies

D Weiss, AS Long, G Tellides, S Avril… - … , and vascular biology, 2022 - Am Heart Assoc
Background: Thoracic aortopathy associates with extracellular matrix remodeling and
altered biomechanical properties. We sought to quantify the natural history of thoracic …

The impact of thickness heterogeneity on soft tissue biomechanics: a novel measurement technique and a demonstration on heart valve tissue

CY Lin, M Mathur, M Malinowski, TA Timek… - … and modeling in …, 2023 - Springer
The mechanical properties of soft tissues are driven by their complex, heterogeneous
composition and structure. Interestingly, studies of soft tissue biomechanics often ignore …