Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …

New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …

A new series of 2-aminobenzothiazole hybrids linked to thiazolidine-2, 4-dione 4a–e, 1, 3, 4-
thiadiazole aryl urea 6a–d, and cyanothiouracil moieties 8a–d was synthesised. The in vitro …

A series of novel indole based sulfonohydrazide derivatives (5a–k) containing morpholine
heterocyclic ring were synthesized through multistep chemical reactions. The target …

Glioma, particularly its most malignant form, glioblastoma multiforme (GBM), is the most
common and aggressive malignant central nervous system tumor. The drawbacks of the …

Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …

Cancer is the most severe disease worldwide. Every year, tens of millions of people are
diagnosed with cancer, and over half of those people will ultimately die from the disease …

Oxadiazoles and thiadiazoles are malleable heterocycles that have recently generated
major interest in the field of medicinal chemistry. Compounds based on these moieties have …

Literature conclusively shows that one of the quinolinequinone analogs (6-anilino-5, 8-
quinolinequinone), referred to as LY83583 hereafter, an inhibitor of guanylyl cyclase, was …