Translation of siRNA technology into the clinic is limited by the need for improved delivery
systems that target specific cell types. Macrophages are particularly attractive targets for …

Tumor necrosis factor-alpha (TNF-α) is a major pro-inflammatory cytokine involved in
systemic inflammation and the acute phase reaction. Dysregulation of TNF production has …

Innate immune signaling by Toll-like receptors (TLRs) involves receptor phosphorylation,
which helps to shape and drive key inflammatory outputs, yet our understanding of the …

Abstract Interleukin-6 (IL-6) is a cytokine largely induced during infection, inflammation, and
cancer. In the liver, IL-6 induces the synthesis of acute-phase proteins, which are believed to …

Synthetic cannabinoids (SCs) have rapidly proliferated as recreational drugs, and may
present a substantial health risk to vulnerable populations. However, information on …

The interest in studying neuroimmune interactions is increasing in the scientific community,
and for many researchers, immunity is becoming a crucial factor in the understanding of the …

The bioactive components of Canavalia lineata (Thunb.) DC pods were investigated using
bioactivity-guided isolation, and the chemical structures of flavonoids 1–3, isoflavonoid …

T-cells are known to be intimately involved in the pathogenesis of multiple sclerosis (MS)
and its animal model experimental autoimmune encephalomyelitis (EAE). T-cell activation is …

Bisphenol A (BPA) is a widely produced, endocrine disrupting compound that is pervasive in
the environment. BPA is a contaminant with increasing exposure to it and exerts both toxic …

Effectively neutralizing inflammatory cytokines is crucial for managing a variety of
inflammatory disorders. Current techniques that target only a subset of cytokines often fall …