Potential pharmacologic treatments for COVID-19 smell and taste loss: A comprehensive review

E Khani, S Khiali, S Beheshtirouy… - European journal of …, 2021 - Elsevier
The acute loss of taste and smell following COVID-19 are hallmark symptoms that affect 20–
85% of patients. However, the pathophysiology and potential treatments of COVID-19 smell …

Olfaction under metabolic influences

B Palouzier-Paulignan, MC Lacroix, P Aimé… - Chemical …, 2012 - academic.oup.com
Recently published work and emerging research efforts have suggested that the olfactory
system is intimately linked with the endocrine systems that regulate or modify energy …

Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning

N Thiebaud, MC Johnson, JL Butler… - Journal of …, 2014 - Soc Neuroscience
Currently, 65% of Americans are overweight, which leads to well-supported cardiovascular
and cognitive declines. Little, however, is known concerning obesity's impact on sensory …

Extrinsic neuromodulation in the rodent olfactory bulb

D Brunert, M Rothermel - Cell and Tissue Research, 2021 - Springer
Evolutionarily, olfaction is one of the oldest senses and pivotal for an individual's health and
survival. The olfactory bulb (OB), as the first olfactory relay station in the brain, is known to …

Molecular characterization of projection neuron subtypes in the mouse olfactory bulb

S Zeppilli, T Ackels, R Attey, N Klimpert, KD Ritola… - Elife, 2021 - elifesciences.org
Projection neurons (PNs) in the mammalian olfactory bulb (OB) receive input from the nose
and project to diverse cortical and subcortical areas. Morphological and physiological …

Olfaction in the context of obesity and diabetes: insights from animal models to humans

M Faour, C Magnan, H Gurden, C Martin - Neuropharmacology, 2022 - Elsevier
The olfactory system is at the crossroad between sensory processing and metabolic
sensing. In addition to being the center of detection and identification of food odors, it is a …

Olfactory system and energy metabolism: a two-way street

P Jovanovic, CE Riera - Trends in Endocrinology & Metabolism, 2022 - cell.com
Olfactory perception guides daily decisions regarding food consumption, social interactions,
and predator avoidance in all mammalian species. Volatile inputs, comprising odorants and …

GLP-1 suppresses feeding behaviors and modulates neuronal electrophysiological properties in multiple brain regions

XY Chen, L Chen, W Yang, AM Xie - Frontiers in molecular …, 2021 - frontiersin.org
The glucagon-like peptide-1 (GLP-1) plays important roles in the regulation of food intake
and energy metabolism. Peripheral or central GLP-1 suppresses food intake and reduces …

Selective Kv1. 3 channel blocker as therapeutic for obesity and insulin resistance

SK Upadhyay, KL Eckel-Mahan… - Proceedings of the …, 2013 - National Acad Sciences
Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1. 3 channel …

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

C Sun, K Tang, J Wu, H Xu, W Zhang, T Cao… - Acta …, 2019 - Wiley Online Library
Aim Leptin is an important peptide hormone that regulates food intake and plays a crucial
role in modulating olfactory function. Although a few previous studies have investigated the …