The mechanisms by which extracellular signals are received and transduced across the cell
membrane are being illuminated by studies in macrophages. In this review Tom Hamilton …

In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer Verlag, Vienna)
that was intended as an up-to-date, comprehensive survey. Whatever success I may have …

A keystone of the molecular reductionist approach to cellular biology is a specific deductive
strategy relating genotype to phenotype—two distinct categories. This relationship is based …

Using [3H] flunitrazepam as a probe for the benzodiazepine-sensitive modulator site located
on the-y-aminobutyric acid (GABA) A receptor complex, we have investigated the cellular …

In previous reports, we have described the use of primary neuronal cultures derived from
chick brain to study the regulation of the-y-aminobutyric acidA (GABAA) receptor complex …

Background Sex steroid hormones influence function of the human gastrointestinal tract.
Although the specific receptor proteins have been identified in surgical specimens of both …

Prostaglandin E 1/I 2 and insulin receptors of human erythrocyte and platelet are capable of
modulating each other's activity. This modulation of the receptor activity and number in one …

Receptor activation can result in changes in receptor function that allow responses to be
modulated according to the environment. This can occur via changes in receptor number or …

In the second of a series of three articles on receptor regulation, Morley Hollenberg identifies
a variety of covalent receptor modifications as well as a number of noncovalent receptor …

Bacteria adapt to changes in their environment by altering their metabolism, turning on and
off genes, and moving toward favorable conditions. Recent results indicate that a common …