The complicated nature of somatic mtDNA mutations in aging
M Sanchez-Contreras, SR Kennedy - Frontiers in aging, 2022 - frontiersin.org
Mitochondria are the main source of energy used to maintain cellular homeostasis. This
aspect of mitochondrial biology underlies their putative role in age-associated tissue …
aspect of mitochondrial biology underlies their putative role in age-associated tissue …
Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations
JD Stumpf, WC Copeland - Cellular and Molecular Life Sciences, 2011 - Springer
DNA polymerase γ (pol γ), encoded by POLG, is responsible for replicating human
mitochondrial DNA. About 150 mutations in the human POLG have been identified in …
mitochondrial DNA. About 150 mutations in the human POLG have been identified in …
Mitochondrial fusion is required for regulation of mitochondrial DNA replication
E Silva Ramos, E Motori, C Brüser, I Kühl… - PLoS …, 2019 - journals.plos.org
Mitochondrial dynamics is an essential physiological process controlling mitochondrial
content mixing and mobility to ensure proper function and localization of mitochondria at …
content mixing and mobility to ensure proper function and localization of mitochondria at …
Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
H Meng, C Yamashita, K Shiba-Fukushima… - Nature …, 2017 - nature.com
Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To
understand the physiological and pathological roles of CHCHD2, we manipulated the …
understand the physiological and pathological roles of CHCHD2, we manipulated the …
Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations
LS Itsara, SR Kennedy, EJ Fox, S Yu, JJ Hewitt… - PLoS …, 2014 - journals.plos.org
The accumulation of somatic mitochondrial DNA (mtDNA) mutations is implicated in aging
and common diseases of the elderly, including cancer and neurodegenerative disease …
and common diseases of the elderly, including cancer and neurodegenerative disease …
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes
M Shaposhnikov, E Proshkina, L Shilova… - Scientific reports, 2015 - nature.com
DNA repair declines with age and correlates with longevity in many animal species. In this
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …
Pheromonal and Behavioral Cues Trigger Male-to-Female Aggression in Drosophila
Appropriate displays of aggression rely on the ability to recognize potential competitors. As
in most species, Drosophila males fight with other males and do not attack females. In …
in most species, Drosophila males fight with other males and do not attack females. In …
[HTML][HTML] Different faces of mitochondrial DNA mutators
K Szczepanowska, A Trifunovic - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
A number of studies have shown that ageing is associated with increased amounts of
mtDNA deletions and/or point mutations in a variety of species as diverse as Caenorhabditis …
mtDNA deletions and/or point mutations in a variety of species as diverse as Caenorhabditis …
Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ
CL Samstag, JG Hoekstra, CH Huang… - PLoS …, 2018 - journals.plos.org
Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and
the accumulation of somatic mtDNA mutations is implicated in aging and common diseases …
the accumulation of somatic mtDNA mutations is implicated in aging and common diseases …
Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations
Succinate-CoA ligase (SUCL) is a heterodimer enzyme composed of Suclg1 α-subunit and
a substrate-specific Sucla2 or Suclg2 β-subunit yielding ATP or GTP, respectively. In …
a substrate-specific Sucla2 or Suclg2 β-subunit yielding ATP or GTP, respectively. In …