Mitochondria are the main source of energy used to maintain cellular homeostasis. This
aspect of mitochondrial biology underlies their putative role in age-associated tissue …

DNA polymerase γ (pol γ), encoded by POLG, is responsible for replicating human
mitochondrial DNA. About 150 mutations in the human POLG have been identified in …

Mitochondrial dynamics is an essential physiological process controlling mitochondrial
content mixing and mobility to ensure proper function and localization of mitochondria at …

Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To
understand the physiological and pathological roles of CHCHD2, we manipulated the …

The accumulation of somatic mitochondrial DNA (mtDNA) mutations is implicated in aging
and common diseases of the elderly, including cancer and neurodegenerative disease …

DNA repair declines with age and correlates with longevity in many animal species. In this
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …

Appropriate displays of aggression rely on the ability to recognize potential competitors. As
in most species, Drosophila males fight with other males and do not attack females. In …

A number of studies have shown that ageing is associated with increased amounts of
mtDNA deletions and/or point mutations in a variety of species as diverse as Caenorhabditis …

Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and
the accumulation of somatic mtDNA mutations is implicated in aging and common diseases …

Succinate-CoA ligase (SUCL) is a heterodimer enzyme composed of Suclg1 α-subunit and
a substrate-specific Sucla2 or Suclg2 β-subunit yielding ATP or GTP, respectively. In …