Vascular cognitive impairment (VCI) is a lifelong process encompassing a broad spectrum of
cognitive disorders, ranging from subtle or mild deficits to prodromal and fully developed …

Lipoprotein lipase (LPL) is a key enzyme in lipid and lipoprotein metabolism. The canonical
role of LPL involves the hydrolysis of triglyceride-rich lipoproteins for the provision of FFAs to …

Managing age-related decrease of cognitive function is an important public health
challenge, especially in the context of the global aging of the population. Over the last years …

Importance The association between hypertension developed before midlife and late-life
brain health is understudied and, because of the cardioprotective benefits of estrogen before …

Aims Elevated blood pressure (BP) is a prevalent modifiable risk factor for cardiovascular
diseases and contributes to cognitive decline in late life. Despite the fact that functional …

Background and objectives Vascular risk factors and elevated β-amyloid (Aβ) are commonly
observed together among older adults. Here, we examined the interactive vs independent …

A novel biomarker panel was proposed to quantify macro and microstructural biomarkers
from the normal-appearing brain matter (NABM) in multicentre fluid-attenuation inversion …

We investigated the associations of plasma neurofilament light (NfL), glial fibrillary acidic
protein (GFAP), and total tau (t-tau) with markers of cerebral small vessel disease (SVD) and …

Objective Residing in communities characterized by socioeconomic disadvantage confers
risk of cardiometabolic diseases. Residing in disadvantaged communities may also confer …

Objective Previous studies have shown that certain severe mental illnesses (SMIs) increase
the risk of dementia, but those that increase the risk to a greater degree in comparison with …