Genetic variant calling from DNA sequencing has enabled understanding of germline
variation in hundreds of thousands of humans. Sequencing technologies and variant-calling …

Cellular barcodes are distinct DNA sequences that enable one to track specific cells across
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …

Short-read sequencing is the workhorse of cancer genomics yet is thought to miss many
structural variants (SVs), particularly large chromosomal alterations. To characterize missing …

The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We
perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
monkeypox virus (MPXV) severely threaten human health; however, currently, no vaccine …

Background: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-
like) family-mediated mutagenesis is widespread in human cancers. However, our …

Jamestown Canyon virus (JCV) is a deadly viral infection transmitted by various mosquito
species. This mosquito-borne virus belongs to Bunyaviridae family, posing a high public …

Research on the immune system and cancer has led to the development of new medicines
that enable the former to attack cancer cells. Drugs that specifically target and destroy …

Background The etiopathogenesis of chronic spontaneous urticaria (CSU) has not been fully
understood, and there has been extensive interest in the interaction between inflammatory …

How chronic mutational processes and punctuated bursts of DNA damage drive evolution of
the cancer genome is poorly understood. Here, we demonstrate a strategy to disentangle …