[HTML][HTML] Q fever immunology: the quest for a safe and effective vaccine

G Sam, J Stenos, SR Graves, BHA Rehm - npj Vaccines, 2023 - nature.com
Q fever is an infectious zoonotic disease, caused by the Gram-negative bacterium Coxiella
burnetii. Transmission occurs from livestock to humans through inhalation of a survival form …

[HTML][HTML] Immunogenicity and reactogenicity in Q fever vaccine development

AP Fratzke, EJ van Schaik, JE Samuel - Frontiers in Immunology, 2022 - frontiersin.org
Coxiella burnetii is an obligate intracellular bacterium which, in humans, causes the disease
Q fever. Although Q fever is most often a mild, self-limiting respiratory disease, it can cause a …

[HTML][HTML] Evaluation of a Human T Cell-Targeted Multi-Epitope Vaccine for Q Fever in Animal Models of Coxiella burnetii Immunity

AE Sluder, S Raju Paul, L Moise, C Dold… - Frontiers in …, 2022 - frontiersin.org
T cell-mediated immunity plays a central role in the control and clearance of intracellular
Coxiella burnetii infection, which can cause Q fever. Therefore, we aimed to develop a novel …

[HTML][HTML] Genome-wide epitope mapping across multiple host species reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection

E Bach, SF Fitzgerald, SE Williams-MacDonald… - Frontiers in …, 2023 - frontiersin.org
Coxiella burnetii is an important zoonotic bacterial pathogen of global importance, causing
the disease Q fever in a wide range of animal hosts. Ruminant livestock, in particular sheep …

[HTML][HTML] Immunisation with purified Coxiella burnetii phase I lipopolysaccharide confers partial protection in mice independently of co-administered adenovirus …

C Dold, H Zhu, L Silva-Reyes, L Blackwell, A Linder… - Vaccine, 2023 - Elsevier
Q fever is a highly infectious zoonosis caused by the Gram-negative bacterium Coxiella
burnetii. The worldwide distribution of Q fever suggests a need for vaccines that are more …

[HTML][HTML] An O-Specific Polysaccharide/Tetanus Toxoid Conjugate Vaccine Induces Protection in Guinea Pigs against Virulent Challenge with Coxiella burnetii

SR Graves, A Islam, LD Webb, I Marsh, K Plain… - Vaccines, 2022 - mdpi.com
Q fever is caused by the bacterium Coxiella burnetii and is spread to humans from infected
animals especially goats, sheep and cattle, predominantly when giving birth. There is an …

Diphtheria Toxoid Particles as Q Fever Vaccine

G Sam, S Chen, K Plain, I Marsh… - Advanced Functional …, 2024 - Wiley Online Library
There is an unmet need for a stable and nonreactogenic vaccine against the bioterrorism
agent, Coxiella burnetii, causing Q fever. Here a safe, effective, and non‐reactogenic Q fever …

Synthetic Particulate Subunit Vaccines for the Prevention of Q Fever

G Sam, K Plain, S Chen, A Islam… - Advanced …, 2024 - Wiley Online Library
Coxiella burnetti is an intracellular bacterium that causes Q fever, a disease of worldwide
importance. Q‐VAX®, the approved human Q fever vaccine, is a whole cell vaccine …

[HTML][HTML] Genome-wide epitope mapping across multiple host species reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection

E Bach, SF Fitzgerald, SE Williams-MacDonald… - Frontiers in …, 2023 - frontiersin.org
Coxiella burnetii is an important zoonotic bacterial pathogen of global importance, causing
the disease Q fever in a wide range of animal hosts. Ruminant livestock, in particular sheep …

[HTML][HTML] Cytometry profiling of ex vivo recall responses to Coxiella burnetii in previously naturally exposed individuals reveals long-term changes in both adaptive …

S Raju Paul, A Scholzen, PM Reeves… - Frontiers in …, 2023 - frontiersin.org
Introduction Q fever, caused by the intracellular bacterium Coxiella burnetii, is considered an
occupational and biodefense hazard and can result in debilitating long-term complications …