[HTML][HTML] Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational …
A de Bartolomeis, A Barone, V Begni, MA Riva - Pharmacological research, 2022 - Elsevier
Antipsychotics represent the mainstay of schizophrenia pharmacological therapy, and their
role has been expanded in the last years to mood disorders treatment. Although introduced …
role has been expanded in the last years to mood disorders treatment. Although introduced …
[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …
data can shed light on the molecular mechanisms underlying the structural and functional …
[HTML][HTML] Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis
The human brain's resting-state functional connectivity (rsFC) provides stable trait-like
measures of differences in the perceptual, cognitive, emotional, and social functioning of …
measures of differences in the perceptual, cognitive, emotional, and social functioning of …
[HTML][HTML] Bridging the gap? Altered thalamocortical connectivity in psychotic and psychedelic states
Psychiatry has a well-established tradition of comparing drug-induced experiences to
psychotic symptoms, based on shared phenomena such as altered perceptions. The present …
psychotic symptoms, based on shared phenomena such as altered perceptions. The present …
[HTML][HTML] Neural circuitry of salience and reward processing in psychosis
The processing of salient and rewarding stimuli is integral to engaging our attention,
stimulating anticipation for future events, and driving goal-directed behaviors. Widespread …
stimulating anticipation for future events, and driving goal-directed behaviors. Widespread …
Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders
C Mu, X Dang, XJ Luo - Nature human behaviour, 2024 - nature.com
Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …
psychiatric disorders. However, the causal relationships between brain resting-state …
Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum
Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic
dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction …
dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction …
Disrupted subcortical functional connectome gradient in drug-naïve first-episode schizophrenia and the normalization effects after antipsychotic treatment
Antipsychotics are thought to improve schizophrenia symptoms through the antagonism of
dopamine D2 receptors, which are abundant mainly in subcortical regions. By introducing …
dopamine D2 receptors, which are abundant mainly in subcortical regions. By introducing …
[HTML][HTML] Circuit-based approaches to understanding corticostriatothalamic dysfunction across the psychosis continuum
Dopamine is known to play a role in the pathogenesis of psychotic symptoms, but the
mechanisms driving dopaminergic dysfunction in psychosis remain unclear. Considerable …
mechanisms driving dopaminergic dysfunction in psychosis remain unclear. Considerable …
Using in silico perturbational approach to identify critical areas in schizophrenia
Schizophrenia is a debilitating neuropsychiatric disorder whose underlying correlates
remain unclear despite decades of neuroimaging investigation. One contentious topic …
remain unclear despite decades of neuroimaging investigation. One contentious topic …