Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex
(ACC) as a site of interest for several neurological and psychiatric conditions. The ACC …

The lateral habenula (LHb) is a tiny structure that acts as a hub, relaying signals from the
limbic forebrain structures and basal ganglia to the brainstem modulatory area. Facilitated …

In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of
melatonin (MLT) on neuropathic pain (NP)-induced anxiety and depression in a rat model …

Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Many
studies have shown that alterations in synaptic plasticity in the anterior cingulate cortex …

The habenula has been implicated in the pathogenesis of pain and analgesia, while
evidence concerning its function in chronic low back pain (cLBP) is sparse. This study aims …

This study aimed to explore the effects and possible mechanisms of intravenous lidocaine in
postherpetic neuralgia (PHN) rats. Mechanical withdrawal thresholds and thermal …

This study evaluates the long-term effects of a six and 14-week morphine withdrawal in rats
pretreated with a cannabinoid agonist (CP-55,940, CP) during periadolescence. Wistar rats …

Trigeminal neuralgia is the most common neuropathic pain involving the craniofacial region.
Due to the complex pathophysiology, it is therapeutically difficult to manage. Noradrenaline …

Trigeminal neuropathic pain has been modeled in rodents through the constriction of the
infraorbital nerve (CCI-ION). Sensory alterations, including spontaneous pain, and thermal …

Chronic postsurgical pain (CPSP) and its emotional comorbidities poses health burden to
patients who have received the surgical treatment. However, its underlying mechanism …