5-lipoxygenase is an enzyme responsible for the synthesis of a range of bioactive lipids
signalling molecules known collectively as eicosanoids. 5-lipoxygenase metabolites such as …

The tumor immune landscape gained considerable interest based on the knowledge that
genetic aberrations in cancer cells alone are insufficient for tumor development …

Abstract The enzyme 5-lipoxygenase (5-LO) is key in the synthesis of leukotrienes, which
are potent proinflammatory lipid mediators involved in chronic inflammatory diseases …

Simple Summary We present eight core attributes of cancer growth that we must address for
a more effective treatment than we currently have. To do this we outline why a regimen …

For colorectal cancer (CRC) patients, local and systemic inflammatory responses have been
extensively reported to closely associate with patient survival. However, the specific …

The objective of this study was to synthesize seven novel thiourea derivatives of naproxen (8–
14), examine the anti-inflammatory activity of the newly synthesized compounds, investigate …

Lipoxygenase (5-LO), a fatty acid oxygenase, is the central enzyme in leukotriene (LT)
biosynthesis, potent arachidonic acid-derived lipid mediators released by innate immune …

Colorectal cancer (CRC) continues to be a major cause of morbidity and mortality. The
arachidonic acid (AA) pathway and linoleic acid (LA) pathway have been implicated as …

Lipoxygenase (5-LO), the central enzyme in the biosynthesis of leukotrienes, is frequently
expressed in human solid malignancies even though the enzyme is not present in the …

Acetaminophen is a commonly used drug that induces serious hepatotoxicity when
overdosed, leading to increased levels of serum aminotransferases. However, little …