Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

Aging is the most important factor contributing to cardiovascular diseases (CVDs), and the
incidence and severity of cardiovascular events tend to increase with age. Currently, CVD is …

Gut microbiota is the largest and most complex microflora in the human body, which plays a
crucial role in human health and disease. Over the past 20 years, the bidirectional …

Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting
subclinical, proinflammatory status, currently recognized as the main risk factor for …

Background During myocardial damage, the sex hormone estrogen and CD73, the main
enzyme that converts AMP into adenosine, are cardioprotective molecules. However, it is …

Today, inactivity and high-calorie diets contribute to the development of obesity and
premature aging. In addition, the population of elderly people is growing due to …

Progressive age-induced deterioration in the structure and function of the cardiovascular
system involves cardiac hypertrophy, diastolic dysfunction, myocardial fibrosis, arterial …

Cardiomyopathies (CMs) are highly heterogeneous progressive heart diseases
characterised by structural and functional abnormalities of the heart, whose intricate …

Macroalgae are considered healthy food ingredients due to their content in numerous
bioactive compounds, and the traditional use of whole macroalgae in Asian cuisine …

Background Preclinical models are often used for cancer studies and evaluation of novel
therapeutics. The relevance of these models has vastly improved with mice bearing a …